It’s really hard to say because it all depends on who you match up against. Take the rams for example. They were in 11 personnel almost exclusively a few years ago. Now they are the in it the least of all nfl teams. They use multiple tightends and backs. A team like the Ravens forces you to have 3-4 LBs on the field most of the game Bc they usually only send out 1 or 2 WRs.
When you are in a true nickel defense whether you run a 3 man front (3-3-5) or a 4 man front(4-2-5)... you’re gonna have 5 DBs either way. The players in the backend won’t change that much it’s more dependent on if your coach prefers more man or zone coverage. Ie: josh Norman. He’s a zone corner, he was great in Carolina and when he went to Washington to a man scheme he struggled.
It’s really about your OLBs, DE, and DTs.