I've been on a good routine as of late. Last two months, my workout schedule has looked like this:
Sunday: Heavy lifting chest and back + Sprints
Monday: Full body circuit training + 30 mins. cardio
Tuesday: Off
Wednesday: Heavy lifting quads and hamstrings
Thursday: Off
Friday: Full body circuit training + 30 mins. cardio
Saturday: Off
I also do core every day, and biceps and calves on days when I'm in the gym. I've had to cut workouts short from time to time because of my right knee. The tendon is bad, so quad workouts tend to be a problem for me.
I've done this, combined with planning my diet better and cutting out soda all together. I only drink water anymore, and maybe 2-3 Gatorade or Arizona Ice Tea a week. I've dropped from 215/220 to 200 even, with noticeable difference, and I've been able to keep most of my muscle mass.