My wish list:
1. Gameplay overhaul time. Option game, blocking, defensive AI all need a complete overhaul.
2. Fleshed out TeamBuilder options with better arenas/uniforms.
3. Better stat/record keeping for coaches and programs. I want to know not just how many bowls or championships I've won, but who against, what year, what the score was, etc.
4. I want a MUCH better transfer system. Players hardly ever, and I mean ever transfer from my school now that it's a dynasty. If the game won't do it automatically, then I want to know that when I manually cut a player (whether he's pretty good or junk) to actually transfer somewhere instead of disappearing into the abyss of deleted players. Have that 3-star I signed that gets recruited over the next year actually have an opportunity to play whether it be at another FBS school or down into the FCS. They don't have to have all the stat-tracking of the FBS schools, but they should have a portion of their seniors merged into the Madden draft classes and have their playoff systems, etc.
5. Still way more randomness tied to types of athletes, more randomness on busts, gems, and progression.
6. The sim engine has been a little better but it should be tied to even more playbook/offense/defense/sub options that vary how your statistics stack up at the end of the year.