In critiquing the original poster's theory, it is important to distinguish between matchups between (1) offensive tackles and defensive ends; and (2) interior offensive linemen vs. defensive tackles. In the latter case, there simply is no substitute for mass, strength and leverage if you hope to hold your own against, let alone defeat, defensive tackles built like Shy Tuttle and Kahlil McKenzie.
A defensible argument can be made, however, for moving toward leaner, more athletic offensive tackles. As a case in point, we all recall that Derek Barnett more than held his own against Brandon Scherff, the Iowa senior offensive tackle, who was selected fifth overall in the 2015 NFL draft. It is quite probable that a third- or fourth-year version of Barnett would have absolutely dominated this highly touted tackle, who often looked slow by comparison.
Barnett is currently listed as 6-3, 257. By the time he graduates or leaves for the NFL draft, he might tip the scales at 265-270. Few tackles in the 300-315 pound range can match his quickness. This parallels the matchup problems that most SEC teams had with Jadeveon Clowney (6-5, 266). Granted, he has freakish talent when he chooses to apply it consistently. Nevertheless, customizing the tackle position to more heavily emphasize quickness and mobility at a lighter and leaner playing weight would seem like a logical course of action if you want to neutralize speed-rushing defensive ends.