You are assuming starters; I don't think we're there yet. So let's keep it generic.
Given who our head coach is, the first play from scrimmage is going to be something physical. Something that depends heavily on the Big Uglies at the LoS.
So it's gonna be a run play, or a run/pass option. It won't be anything fancy. No trick play, no deep throw, no reverse or draw. It will be something that says "we play power football here, once again."
So my guess is a run between the tackles with a lead blocker (FB or TE or both). If not that, a run/pass option or a run just off the tackle's outside shoulder.
The formation will be the I or offset-I. If single-back, there will be a tight end tucked in off the shoulder of a tackle.
That's what I'd put my money on, something in that grouping.