Looking back through the history books, I think the toughest opener ever faced by a Vols coach may have been the start of General Neyland's third stint, in 1946, when he faced off against one of his former players, Bobby Dodd, and the Georgia Tech Yellow Jackets. Tennessee won that opener 13-9, but the Jackets went on to post a 9-2 season.
If you rule that game out because Neyland had coached at Tennessee before (in two other stretches, even), then maybe the toughest career opener ever for a Vols coach was Bowden Wyatt's 1955 game against the Miss State Bulldogs. We lost that one, 7-13. Coach Darrell Royal was in his 2nd season. MSU ended the season 6-4.
Will our opener this year against West Virginia be as tough as either of those games? Hard to tell, because we don't yet know how good West Virginia's squad will prove to be. It could be up there with the toughest, though.
Certainly a lot tougher than J.D. DePree's opener in 1905 against the Tennessee School for the Deaf.