Lynchburg is bigger. Better hotel and restaurant choices.
If you don't mind driving a little bit for shopping, Roanoke is better. It's 45 minutes west. The mall is bigger and nicer. On Saturday morning there is a farmers/craft market downtown Roanoke plus some really cool shops.
Bedford is 20 minutes west on the way to Roanoke. National D-Day Memorial is there. 20 minutes north of Bedford is the Peaks of Otter on the Blue Ridge Parkway. Hike to the top (1 mile) for a 360 view of the fall colors.
Appomattox is 30 minutes northeast. Courthouse where Lee surrendered to Grant and civil war battlefields.
Charlottesville is an hour north. Monticello, Thomas Jeffersons home, is there. Great shopping and restaurants there also. Route 20 going north from Charlottesville passes through several civil war battlefields. It's a pretty drive through horse farms.
Hope this helps.
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