President Donald Trump - J.D. Vance Administration

#41,901
#41,901
Vol737 said:
This is what I found. SIAP. The concern wrt Tylenol stems from it depletion of glutathione needed for mitochondrial and cellular function and development. The depletion of glutathione suggests it could be playing a role in the increased cases of autism. @kiddiedoc @NurseGoodVol..what is your take on this info?

Tylenol (
acetaminophen) can deplete glutathione in the body, particularly mitochondrialand intracellular stores, and also inhibit glutathione reductase, an enzyme essential for glutathione recycling. This depletion and inhibition contribute to oxidative stress and can be part of the mechanism behind acetaminophen-induced toxicity, especially during overdose.
Mechanism of Glutathione Depletion

  1. Reactive Metabolite Formation: Acetaminophen is metabolized in the liver to a reactive metabolite called NAPQI.
  2. Glutathione Conjugation: Glutathione is a key antioxidant that neutralizes toxic substances by forming conjugates. The reactive NAPQI metabolite can bind with glutathione, using it up.
  3. Depletion of Stores: With a high dose of acetaminophen or an overdose, the amount of NAPQI produced can overwhelm the body's glutathione stores, leading to significant depletion.
  4. Inhibition of Glutathione Reductase: Research suggests that acetaminophen can inhibit glutathione reductase, an enzyme that regenerates glutathione from its oxidized form. This further impairs the body's ability to maintain adequate glutathione levels.
Consequences of Glutathione Depletion

  • Increased Oxidative Stress: With reduced glutathione, the body's ability to fight oxidative stress decreases, which can lead to cellular damage.
  • Hepatotoxicity (Liver Toxicity): In the liver, glutathione plays a crucial role in detoxification. Depletion can lead to liver cell damage.
  • Impact on Other Organs: Glutathione depletion has also been observed in other tissues, including the lungs and brain, suggesting a broader systemic impact.
^^^This last sentence is interesting, but sounds like there would have to be over use of Tylenol well beyond the prescribed amount to have such an impact, but that’s me just spitballing.
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My neonatology class was like 18 years ago and so I think @kiddiedoc would be who I would defer to. I specialized in adult nursing.
I can tell you the CDC recommendations for daily Tylenol use changed about 5 years ago from 4G a day to 3G a day.
I have had a hundred Tylenol OD’s in 19 years and we run Acetadote(acetylcysteine) drips that replenish glutathiones to reduce liver damage.
Overuse of any drug is bad because they all come with side effects. Only when needed and for the shortest time possible is good advice.
Public service announcement!!!
Oh and there is a recall on coreg and metoprolol. 2 very common meds for hypertension so please check for the recall on those drugs if you are currently taking them and contact your pharmacy if you have the recall lot numbers.
 
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#41,902
#41,902
NurseGoodVol said:
My neonatology class was like 18 years ago and so I think @kiddiedoc would be who I would defer to. I specialized in adult nursing.
I can tell you the CDC recommendations for daily Tylenol use changed about 5 years ago from 4G a day to 3G a day.
I have had a hundred Tylenol OD’s in 19 years and we run Acetadote(acetylcysteine) drips that replenish glutathiones to reduce liver damage.
Overuse of any drug is bad because they all come with side effects. Only when needed and for the shortest time possible is good advice.
Public service announcement!!!
Oh and there is a recall on coreg and metoprolol. 2 very common meds for hypertension so please check for the recall on those drugs if you are currently taking them and contact your pharmacy if you have the recall lot numbers.
Click to expand...
What about this Doctor comments. They seem interesting

 
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#41,904
#41,904
OHvol40 said:
Autism was first described in 1911, acetaminophen wasn’t available as an OTC drug until 1960 after being first introduced in 1955. Risk for autism can be found in your genome. Please do not subscribe to garbage like this just because of who’s saying it.
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You’re confusing “cause” and “risk”. Cancer occurred before cigarettes. Cigarettes still increase the risk of numerous cancers.
 
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#41,905
#41,905
lawgator1 said:
Ok.

But when Trump or his sons minimize Russian meddling, be prepared for the next Dem DOJ to indict them for perjury. And to fire any Assistant US Attorney who refuses to do so.

What's good for the goose ....
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Do you think the right “minimizing Russian meddling” has anything to do with the left weaponizing Russian meddling (a thing that occurs in every election) as a means to launch an FBI investigation into the Trump campaign?

Just a thought.

Weird too how we’ve never really heard the left talk much about Russian meddling in the 2008 election, 2012 election, or the 2020 election. Did Russia take those years off?
 
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#41,907
#41,907
n_huffhines said:
What does that point have anything to do with what we're talking about? The point of bringing up 1967 is to show you the US did not support Palestinians that were suffering at the hands of Israel, like you indicated we would this time. You are pivoting to talk about whether or not 1967 was justified. If 1967 was justified because of your point about Canaan, then taking Gaza now is also justified.
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I said 95% of Americans. I wasn’t around in 1967, so could you point me to a poll or article that shows how Americans felt in 1967?
 
#41,911
#41,911
swampfoxfan said:
Meanwhile, the Russia/Ukraine War go on as does the Israeli war. Grocery prices continue to rise and farmers are going bankrupt. School children being murdered gets nothing but thoughts and prayers, even when the kids are killed while praying.
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Last time I looked at the data, it proclaimed school shootings were down significantly since the 1990s.

Do you intend on just throwing this dumb virtue signal out forever and independent of data?
 
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#41,912
#41,912
appvol said:
What about what this Doctor comments. They seem interesting

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Interesting and as far as older adults that’s a yes. Again I’m gonna defer to @kiddiedoc for the babies.

Each Pt is different and runs a fever for a reason. Fevers can be beneficial at times and other times be damaging (tachycardia). If it’s harmful we have a laundry list of interventions we can do before Tylenol. I always taught my orientees to do all those interventions first. Sometimes it was as simple as removing the 8 blankets a family member piled on the pt or “ what do you keep your thermostat at home on?” 68*… turning the thermostat down from 76*.
 
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#41,914
#41,914
n_huffhines said:
Also, you know that Israel attacked the Arab states, took their territories, and began a 50-year illegal occupation of them, violating international law...and right after that, that's when the United States BEGAN to fully support Israel.

So from the perspective of a Palestinian, I don't think they'd look at it the way you do. 95% of Americans didn't support them that time.
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I am anti-israeli government actions to be called nazi/terrorist/anti-semitic/racist; but you really need to show some math here.
 
#41,921
#41,921
Willy P said:
It's amazing to me that you aren't able to say you disapprove of the Israeli government's actions without being called an anti-Semite.
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people don't have a real argument so they just default to the good ole "racist" card; instead of admitting the state of Israel and all of its actions aren't literally perfect in every way and deserving of unending, blind, unquestioning support from the US.
 
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