Pass defense is nonexistent. The worst QB in the game can still complete 75 percent of his passes, and the defensive backs don't even try to intercept the ball most times.
Edit: Also, the CPU QB will throw the ball away IMMEDIATELY if one of the receivers isn't open. Annoying for two reasons: 1) the CPU cops out every single time when you finally make a good defensive call, and 2) this should be intentional grounding, yet it's never called.
The game made good improvements overall, but they took some steps back on defense.