I would say it would be harder for a team like USC to go undefeated in the Big 12 where they would have to play other elite level teams like Oklahoma and Texas every year than it is in the Pac-10 where they play a consistent schedule of lesser talented teams.
I completely disagree. Look at Texas' and Oklahoma's schedules this year. Cupcake city. Yes they play eachother, but no one else. SC would roll with such a schedule. And what if they were in nebraska's division and didn't have to play both texas and oklahoma?