Even in your scenario, the OG merely made a play that the C missed. He could have made the same play had he hated the center. He could have made the same play if he was going out with the center's girlfriend, or vice versa. Chemistry has ZERO to do with it. The guard has a job to do, and no "chemistry" caused him to do his job. He was talented enough--both physically and mentally--to make that play. No chemistry needed.
It is said that some qb's have "chemistry" with a wideout. That's just coach-speak that they have thrown hundreds of balls together, practiced hard, and know through experience what to expect. Where is the "chemistry"? There is none.
As applied to another sport, its like Earl Weaver said: "Chemistry is all about getting good pitching and three run home runs."