IMO depends on if we're able to jump to a lead or not. If we make them have to pass it, we have a chance at keeping them from putting up numbers like UK last week. Their offense is predicated on the quick passing game, which I think we're better equipped to deal with defensively at this point than UK's running game.
Lock doesn't really run the ball that much, so (in theory at least) we should be able to key in on Mizzou's RBs better than we did against UK (who really gashed us on some zone read plays where guys were out of position).
So I'm going to say that we keep Mizzou under 250 rushing but give up about 250-300 through the air.