Recruiting Forum Football Talk III

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#13,263
#13,263
I am sooooo down to squabble over particulars over the next guy as HC. I'd love that debate as long as we all mutually agree that we need a change. We can debate the particulars afterward.
 
#13,271
#13,271
sutro said:
Personally, I was waiting on the protein-based vaccines (novovax) due to more tried-and-true technology. However, a few things have combined to change my mind. First, the situation on the ground here has dramatically worsened, and my baseline risk for COVID just from doing my job has increased dramatically over the last month, with no signs of the current surge abating until well into next year. Second, aside from folks who have had previous severe allergic reactions, there haven't been much in the way of major side effects seen in the Moderna and Pfizer trials. The proteome analysis on the pfizer vaccine has shown that the only cross-reactivity seems to be with placental proteins, so may not be the best choice for women of reproductive age. Autoimmune complications from COVID infection itself are probably significantly more common. It seems that immunity may be across a broader number of cell types, more robust and more long-lasting than with actual viral infection, potentially due to the actual virus actively shutting down certain parts of the immune system.

My wife (MD/PhD who has done way more research on this than I have) has gradually warmed up to the idea of either the Pfizer or Moderna vaccines after a lot of initial skepticism. I would probably wait on getting the Astra-Zeneca or one of the other viral vector vaccines, as the trials there have been mixed, and the data suggest that there's a chance that the standard dosing actually produces too strong of an initial immune response to the chimpanzee adenovirus vector, causing the second dose to be ineffective because it is destroyed by your immune response before it has a chance to really work.

Here's a podcast link that goes more into depth about the mechanism and trials behind the current mRNA vaccines. Deeper Dive link

We both plan to get one of the two when it becomes available here. Not thrilled about the prospect of not having hundreds of thousands of prior doses and years of followup, but less thrilled about rolling the dice on the potential for weeks in the ICU and long-term complications or worse. I'll let you know if I become a zombie, assuming I can still type.
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If you have severe allergies and need to carry the EpiPen, you might want to stay away from the Pfizer vaccine. Results from the UK said that patients, who took the Pfizer vaccine, with severe allergies, had really bad reactions after being vaccinated. Just some food for thought.
 
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