Louisville and Tennessee have met 19 times on the basketball court dating back to 1913.
The Vols have dropped the last five in the series and 12 of the last 13.
Louisville bounced Tennessee from the 2008 NCAA Tournament, winning 79-60 in a Sweet Sixteen game in Charlotte.
The Cardinals won in Knoxville in 2003 and 2004 and in Louisville in 2001 and 2005.
Tennessee’s last win against Louisville was March. 29, 1985 in New York City, winning 100-84.