I'd say the Golden Knights have the best shot to pull off a big upset this week. USF is a good team, but UCF will be ready for them.
Vandy's got a chance with Georgia today. The Dores beat them last year as big underdogs, and they get UGA in Nashville today...I still expect Georgia to end their SEC East drought with a win today though.
I'd like to see the Tar Heels beat the Cocks in Chapel Hill, but Butch's boys will need to finish the game +2 in turnover margin to do it. South Carolina has had trouble stopping the run, so if the Heels can get Anthony Elzy and Ryan Houston running downfield and force Smelley into a few turnovers, they could pull it off.
I can't see Notre Dame going on the road and beating Boston College. ND was able to capitalize on 7 UCLA turnovers last week, while the Bruins played without Ben Olsen. BC won't lose Matt Ryan, and Matt Ryan won't allow his offense to turn the ball over 7 times.