The Cardinals have failed with almost all their 1st round picks, but in some cases I can't blame them. I liked the Simmons pick, too. They didn't extend Reddick because he didn't produce at all in the first 3 years, and then has 12 sacks (under Joseph) his 4th year, and then he's gone. Maybe they squandered him, but the actual decision to not extend him is defensible.
However, it's hard to give them any benefit of the doubt on anything when this is their resume of 1st round picks:
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And maybe worst of all is that they drafted Isabella with a 2nd round pick instead of Metcalf, who is torching them at a division rival.