The teams that will eventually get left behind (all your non-UNC, non-UVA, non-Miami, non-Clemson, non-FSU, non-Notre Dame, non-Colorado, non-Utah, probably-non-Arizona schools) are likely going to end up settling in a way where the dramatically growing differences in finances over time will essentially make the remainders of the ACC and Big 12 the new (in all but name) midmajor/Group of 5 level equivalents.
Likewise, the schools from the current midmajor/Group of 5 level that aren’t picked up by the Big 12 and ACC to patch up their holes are probably going to end up becoming - functionally - the equivalent (in all but name) of FCS-level over time with the dramatic, increasing financial growth differences.
They’ll be absolutely fine. Unless the playoffs system reaches a point of “the only teams eligible are Big10/SEC members and conference champion winners” and “all revenues generated by the playoffs will not go to any schools who aren’t SEC and Big 10 members” (which spoiler alert: by that point, all the major, big brand, money-making schools will either be part of the two or have made some fiscal, contractual agreement/tie in place with one or both of them), they’re not going to have anything to worry about. They’re too big of a brand name and bring in too much sports revenue as a school to have to worry about being left/pushed out (ie, the overall system gains a lot more fiscally by having them involved than keeping them out of it). As far as schools that should be concerned go, they’re going to be fine.