I haven’t kept up with the newer Mustangs and don’t know what the bolton potential is right now. Back in the early 2000’s they responded well to headers and new heads though yes.
As for the fuel system just find out what it came with and you will know what you need to do. But if you start at 450HP you already have a fuel pump and injectors sized for that and probably more.
Think of a fuel injected engine like an air pump. Air is horsepower because the computer knows the amount of air entering the engine and thus adds the right amount of fuel to that air to hit the proper ratio and the fuel has a specific amount of energy that is released when burned. What you are doing by adding or reworking heads, adding headers, etc is increasing volumetric efficiency. This is why a turbo or super charger works so well because it just stuffs more air in there.
But a Coyote 5L making 450HP already has to be making pretty damn good volumetric efficiency. Back in my days we would hope to get my 4.6L DOHC up to around 450HP with ported heads, headers, reworked cams, and intake work and it wasn’t easy. This crosses brands too. Any modern engine is just an air pump. There are calculators out there I’m sure to help with this too.
but I will tell you this. If you’ve got a real 450HP street car with street legal tires it’s going to be a handful anyway if you aren’t used to it. Learn to drive that car first and educate yourself while doing that.
Hope this answered some questions.