Worst has to be when Peyton and the Broncos were destroyed by the Seahawks. Only memorable thing about that game is that I was in the Philippines and watched it live on Monday morning.
Best, well, I'm a Chiefs fan so...
But also. Eli beating the Pats in 2007ish was great. And the Pats coming back and beating the Falcons was just crazy. The Titans Super Bowl - 2000? - was a good game. So, so close.