Several teams - UK, Arizona, Villanova, Duke (yes, even though they just beat them), Virginia, Wisconsin, Iowa State, Gonzaga, questionably the Kansas/Maryland/Baylor contingent of "eh" teams that I don't expect much from. Notre Dame would have the worst defense of anyone to make a Final Four in the KenPom (since 2002) era.
All of this sets up very well for a Round of 32 loss to, say, Providence. They're outstanding from deep, but Mike Brey has never made it past the Sweet Sixteen and their flaws (bad at forcing turnovers, bad at creating second chances with ORebs, mediocre at shot defense) will limit them to that at best.